Issue 6, 2013
From the journal:

Green Chemistry

Efficient synthesis of quinazoline-2,4(1H,3H)-diones from CO2 and 2-aminobenzonitriles in water without any catalyst

Jun Ma,a   Buxing Han,*a   Jinliang Song,a   Jiayin Hu,a   Wenjing Lu,a   Dezhong Yang,a   Zhaofu Zhang,a   Tao Jianga  and  Minqiang Houa  

* Corresponding authors

a Beijing National Laboratory of Molecular Science, Institute of Chemistry, Chinese Academy of Sciences, No 2, Zhongguancun Beiyijie, Haidian, Beijing, China
E-mail: Hanbx@iccas.ac.cn
Fax: (+) 8610-62562821

Abstract

We discovered that the synthesis of quinazoline-2,4(1H,3H)-diones from CO2 and 2-aminobenzonitriles could proceed efficiently in water without any catalyst and excellent yields were obtained, while the reaction did not occur in organic solvents. This green and simple route to synthesize quinazoline-2,4(1H,3H)-diones has great potential for application.

Graphical abstract: Efficient synthesis of quinazoline-2,4(1H,3H)-diones from CO2 and 2-aminobenzonitriles in water without any catalyst

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Article information

DOI
https://doi.org/10.1039/C3GC00091E
Article type
Communication
Submitted
12 Jan 2013
Accepted
19 Mar 2013
First published
19 Mar 2013

Green Chem., 2013,15, 1485-1489

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Efficient synthesis of quinazoline-2,4(1H,3H)-diones from CO2 and 2-aminobenzonitriles in water without any catalyst

J. Ma, B. Han, J. Song, J. Hu, W. Lu, D. Yang, Z. Zhang, T. Jiang and M. Hou, Green Chem., 2013, 15, 1485 DOI: 10.1039/C3GC00091E

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