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Issue 11, 2013
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Honeysuckle anthocyanin supplementation prevents diet-induced obesity in C57BL/6 mice

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Abstract

This study investigated the anti-obesity effects of honeysuckle anthocyanins (HA) in a high fat diet-induced mouse model. The mice were initially fed with a low-fat diet (LFD) or high-fat diet (HFD) for 8 weeks. After that, the HFD-fed mice were divided into five groups, with 12 mice in each group, including a HFD group, a HFD plus Orlistat group, and three HFD plus HA (at a dose of 50, 100, or 200 mg kg−1) groups, for another 8-week experiment. HA at 100 or 200 mg kg−1 can suppress body weight gain, reduce serum and liver lipid profiles, ameliorate impaired hepatic function, and significantly increase serum adiponectin concentration while decreasing serum insulin and leptin levels. These results suggest that the anti-obesity effect of HA might be through the blockage of lipid accumulation.

Graphical abstract: Honeysuckle anthocyanin supplementation prevents diet-induced obesity in C57BL/6 mice

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Publication details

The article was received on 03 Jul 2013, accepted on 08 Sep 2013 and first published on 09 Sep 2013


Article type: Paper
DOI: 10.1039/C3FO60251F
Citation: Food Funct., 2013,4, 1654-1661
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    Honeysuckle anthocyanin supplementation prevents diet-induced obesity in C57BL/6 mice

    T. Wu, Z. Yu, Q. Tang, H. Song, Z. Gao, W. Chen and X. Zheng, Food Funct., 2013, 4, 1654
    DOI: 10.1039/C3FO60251F

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