Jump to main content
Jump to site search

Issue 5, 2013
Previous Article Next Article

Rutin and quercetin, bioactive compounds from tartary buckwheat, prevent liver inflammatory injury

Author affiliations

Abstract

Tartary buckwheat (Fagopyrum tataricum) is a healthy and nutritionally important food item. In this study, we investigated the hepatoprotective effects of 75% ethanol extracts from tartary buckwheat (EEB) against ethanol- and carbon tetrachloride (CCl4)-induced liver damage. EEB were administered to C57BL/6 mice (ethanol induction) and Sprague-Dawley (SD) rats (CCl4 induction) for 4 and 8 consecutive weeks, respectively. The major active compounds, rutin and quercetin, were also administered to ethanol- and CCl4-induced animals. EEB inhibited increase in serum aspartate transaminase (AST), alanine transaminase (ALT) and alkaline phosphatase (ALP) levels in the ethanol- and CCl4-induced animals; similar effects were found after rutin and quercetin administration. Moreover, EEB elevated the antioxidant enzyme activities, including those of catalase (CAT), glutathione peroxidase (GPx), glutathione reductase (GR), and superoxide dismutase (SOD), and inhibited the levels of hepatic inflammation in the ethanol- and CCl4-treated animals. This study suggests that EEB exerts hepatoprotection via promoting anti-oxidative and anti-inflammatory properties against oxidative liver damage.

Graphical abstract: Rutin and quercetin, bioactive compounds from tartary buckwheat, prevent liver inflammatory injury

Back to tab navigation

Supplementary files

Publication details

The article was received on 26 Dec 2012, accepted on 18 Mar 2013 and first published on 15 Apr 2013


Article type: Paper
DOI: 10.1039/C3FO30389F
Citation: Food Funct., 2013,4, 794-802
  •   Request permissions

    Rutin and quercetin, bioactive compounds from tartary buckwheat, prevent liver inflammatory injury

    C. Lee, S. Shen, Y. Lai and S. Wu, Food Funct., 2013, 4, 794
    DOI: 10.1039/C3FO30389F

Search articles by author

Spotlight

Advertisements