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Issue 3, 2013
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Phyto-power dietary supplement potently inhibits dimethylnitrosamine-induced liver fibrosis in rats

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Abstract

Curcumin has been extensively studied for its therapeutic effects in a variety of disorders. Fermented soy consumption is associated with a low incidence rate of chronic diseases in many Asian countries. The aim of this study was to investigate the potential underlying mechanisms of the effect of a phyto-power dietary supplement on liver fibrosis. Sprague-Dawley rats were intraperitoneally injected with dimethylnitrosamine (DMN; 10 mg kg−1) three times a week for four consecutive weeks. A phyto-power dietary supplement (50 or 100 mg kg−1) was administered by oral gavage daily for four weeks. Liver morphology, function, and fibrotic status were examined in DMN induced hepatic fibrogenesis. However, a phyto-power dietary supplement alleviated liver damage as indicated by histopathological examination of the α-smooth muscle actin (α-SMA) and collagen I, accompanied by the concomitant reduction of transforming growth factor-β1 (TGF-β1) and matrix metalloproteinase 2 (MMP2). These data indicate that the phyto-power dietary supplement may inhibit the TGF-β1/Smad signaling and relieve liver damage in experimental fibrosis.

Graphical abstract: Phyto-power dietary supplement potently inhibits dimethylnitrosamine-induced liver fibrosis in rats

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Publication details

The article was received on 31 Oct 2012, accepted on 08 Dec 2012 and first published on 10 Dec 2012


Article type: Paper
DOI: 10.1039/C2FO30306J
Food Funct., 2013,4, 470-475

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    Phyto-power dietary supplement potently inhibits dimethylnitrosamine-induced liver fibrosis in rats

    M. Lee, M. Tsai, P. Sun, L. Chien, A. Cheng, N. J. Ma, C. Ho and M. Pan, Food Funct., 2013, 4, 470
    DOI: 10.1039/C2FO30306J

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