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Volume 166, 2013
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New RGD-peptide amphiphile mixtures containing a negatively charged diluent

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Abstract

Here, we studied the self-assembly of two peptide amphiphiles, C16-Gly-Gly-Gly-Arg-Gly-Asp (PA 1: C16-GGG-RGD) and C16-Gly-Gly-Gly-Arg-Gly-Asp-Ser (PA 2: C16-GGG-RGDS). We showed that PA 1 and PA 2 self-assemble into nanotapes with an internal bilayer structure. C16 chains were highly interdigitated within the nanotape cores, while the peptide blocks formed water-exposed β-sheets too. PA 1 nanotapes were characterized by one spacing distribution, corresponding to a more regular internal structure than that of PA 2 nanotapes, which presented two different spacing distributions. We showed that it is possible to obtain homogeneous nanotapes in water by co-assembling PA 1 or PA 2 with the negatively charged diluent C16-Glu-Thr-Thr-Glu-Ser (PA 3: C16-ETTES). The homogeneous tapes formed by PA 1–PA 3 or PA 2–PA 3 mixtures presented a structure similar to that observed for the corresponding pure PA 1 or PA 2 nanotapes. The mixed nanotapes, which were able to form a stabilized matrix containing homogeneously distributed cell adhesive RGD groups, represent promising materials for designing new cell adhesion substrates.

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Publication details

The article was received on 26 Apr 2013, accepted on 24 May 2013 and first published on 28 May 2013


Article type: Paper
DOI: 10.1039/C3FD00064H
Citation: Faraday Discuss., 2013,166, 381-397

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    New RGD-peptide amphiphile mixtures containing a negatively charged diluent

    V. Castelletto, R. M. Gouveia, C. J. Connon and I. W. Hamley, Faraday Discuss., 2013, 166, 381
    DOI: 10.1039/C3FD00064H

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