Jump to main content
Jump to site search
PLANNED MAINTENANCE Close the message box

Scheduled maintenance work on Wednesday 27th March 2019 from 11:00 AM to 1:00 PM (GMT).

During this time our website performance may be temporarily affected. We apologise for any inconvenience this might cause and thank you for your patience.


Issue 27, 2013
Previous Article Next Article

Structural and biological implications of the binding of Leu-enkephalin and its metal derivatives to opioid receptors

Author affiliations

Abstract

Binding of Leu-enkephalin and [RhIII5-Cp*)(η6-Tyr1)]Leu-enkephalin to the recently published crystal structures of the μ- and δ-opioid receptor is studied. Docking of free Leu-enkephalin reveals two preferred conformations, one of which suggests an alternative binding site for the tyrosine residue. Furthermore, the three-dimensional solution structure of [RhIII5-Cp*)(η6-Tyr1)]Leu-enkephalin was solved by using 2D NMR spectroscopic techniques.

Graphical abstract: Structural and biological implications of the binding of Leu-enkephalin and its metal derivatives to opioid receptors

Back to tab navigation

Supplementary files

Publication details

The article was received on 23 Dec 2012, accepted on 08 Mar 2013 and first published on 22 Mar 2013


Article type: Communication
DOI: 10.1039/C3DT50635E
Citation: Dalton Trans., 2013,42, 9799-9802

  •   Request permissions

    Structural and biological implications of the binding of Leu-enkephalin and its metal derivatives to opioid receptors

    F. Wieberneit, A. Korste, H. B. Albada, N. Metzler-Nolte and R. Stoll, Dalton Trans., 2013, 42, 9799
    DOI: 10.1039/C3DT50635E

Search articles by author

Spotlight

Advertisements