Issue 28, 2013
From the journal:

Dalton Transactions

A model radiopharmaceutical agent targeted to translocator protein 18 kDa (TSPO)†

Sara Piccinonna,a   Nicola Margiotta,*a   Nunzio Denora,b   Rosa Maria Iacobazzi,b   Concetta Pacifico,a   Giuseppe Trapanib  and  Giovanni Natile*a  

* Corresponding authors

a Dipartimento di Chimica, Università degli Studi di Bari Aldo Moro, Via E. Orabona 4, Bari, Italy
E-mail: nicola.margiotta@uniba.it, giovanni.natile@uniba.it
Tel: +39 080 5442759

b Dipartimento di Farmacia-Scienze del Farmaco, Università degli Studi di Bari Aldo Moro, Via E. Orabona 4, Bari, Italy

Abstract

A stable Re complex containing an imidazopyridine ligand with a high affinity for TSPO has been synthesized as a model for new 99mTc or 188/186Re-based radiopharmaceuticals to be used in SPECT diagnosis or in therapy, respectively. The new complex fac-[ReBr(CO)3(TZ6)], structurally characterized, showed high affinity (nanomolar concentration) for the target protein.

Graphical abstract: A model radiopharmaceutical agent targeted to translocator protein 18 kDa (TSPO)

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Article information

DOI
https://doi.org/10.1039/C3DT51152A
Article type
Communication
Submitted
02 May 2013
Accepted
21 May 2013
First published
21 May 2013

Dalton Trans., 2013,42, 10112-10115

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A model radiopharmaceutical agent targeted to translocator protein 18 kDa (TSPO)

S. Piccinonna, N. Margiotta, N. Denora, R. M. Iacobazzi, C. Pacifico, G. Trapani and G. Natile, Dalton Trans., 2013, 42, 10112 DOI: 10.1039/C3DT51152A

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