Jump to main content
Jump to site search

Issue 27, 2013
Previous Article Next Article

Structural and biological implications of the binding of Leu-enkephalin and its metal derivatives to opioid receptors

Author affiliations

Abstract

Binding of Leu-enkephalin and [RhIII5-Cp*)(η6-Tyr1)]Leu-enkephalin to the recently published crystal structures of the μ- and δ-opioid receptor is studied. Docking of free Leu-enkephalin reveals two preferred conformations, one of which suggests an alternative binding site for the tyrosine residue. Furthermore, the three-dimensional solution structure of [RhIII5-Cp*)(η6-Tyr1)]Leu-enkephalin was solved by using 2D NMR spectroscopic techniques.

Graphical abstract: Structural and biological implications of the binding of Leu-enkephalin and its metal derivatives to opioid receptors

Back to tab navigation

Supplementary files

Article information


Submitted
23 Dec 2012
Accepted
08 Mar 2013
First published
22 Mar 2013

Dalton Trans., 2013,42, 9799-9802
Article type
Communication

Structural and biological implications of the binding of Leu-enkephalin and its metal derivatives to opioid receptors

F. Wieberneit, A. Korste, H. B. Albada, N. Metzler-Nolte and R. Stoll, Dalton Trans., 2013, 42, 9799
DOI: 10.1039/C3DT50635E

Social activity

Search articles by author

Spotlight

Advertisements