Issue 15, 2013
From the journal:

Dalton Transactions

Zinc sensors with lower binding affinities for cellular imaging†

Jin Hoon Kim,a   In Hong Hwang,a   Seung Pyo Jang,ab   Juhye Kang,a   Sumi Kim,c   Insup Noh,c   Youngmee Kim,d   Cheal Kim*a  and  Roger G. Harrison*b  

* Corresponding authors

a Department of Fine Chemistry, Seoul National University of Science and Technology, Seoul 139-743, Korea
E-mail: chealkim@seoultech.ac.kr

b Department of Chemistry and Biochemistry, Brigham Young University, Provo, Utah, USA
E-mail: roger_harrison@byu.edu

c Department of Chemical Engineering, Seoul National University of Science and Technology, Seoul 139-743, Korea

d Department of Chemistry and Nano Science, Ewha Womans University, Seoul 120-750, Korea

Abstract

Zinc sensors based on 2,3-dipicolylamine (DPA) and quinoline have been synthesized. They fluoresced in the presence of Zn2+ and remained fluorescent when other metal ions were present. Fluorescence enhancement of the sensors was not seen for most other metal ions. In vitro studies with fibroblasts showed fluorescence when sensor and Zn2+ were present. As seen by single crystal X-ray analysis, four nitrogens from the sensor bind to Zn2+. These new sensors have lower binding constants than the pentadentate sensors based on 2,2-DPA.

Graphical abstract: Zinc sensors with lower binding affinities for cellular imaging

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Article information

DOI
https://doi.org/10.1039/C3DT33024A
Article type
Paper
Submitted
17 Dec 2012
Accepted
10 Feb 2013
First published
11 Feb 2013

Dalton Trans., 2013,42, 5500-5507

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Zinc sensors with lower binding affinities for cellular imaging

J. H. Kim, I. H. Hwang, S. P. Jang, J. Kang, S. Kim, I. Noh, Y. Kim, C. Kim and R. G. Harrison, Dalton Trans., 2013, 42, 5500 DOI: 10.1039/C3DT33024A

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