Issue 13, 2013
From the journal:

Dalton Transactions

Straightforward approach to efficient oxidative DNA cleaving agents based on Cu(ii) complexes of heterosubstituted cyclens†

Jan Hormann,a   Chrischani Perera,a   Naina Deibel,ab   Dieter Lentz,a   Biprajit Sarkara  and  Nora Kulak*a  

* Corresponding authors

a Institut für Chemie und Biochemie, Freie Universität Berlin, Fabeckstr. 34/36, D-14195 Berlin, Germany
E-mail: nora.kulak@fu-berlin.de
Fax: +49 30 838 52440
Tel: +49 30 838 54697

b Universität Stuttgart, Institut für Anorganische Chemie, Pfaffenwaldring 55, 70569 Stuttgart, Germay

Abstract

The Cu(II) complexes of cyclen and two of its heterosubstituted analogues were shown to be efficient oxidative DNA cleavers. The reactivity strongly depends on the heteroatom inserted into the macrocycle (O > S > N).

Graphical abstract: Straightforward approach to efficient oxidative DNA cleaving agents based on Cu(ii) complexes of heterosubstituted cyclens

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Article information

DOI
https://doi.org/10.1039/C3DT32857K
Article type
Communication
Submitted
28 Nov 2012
Accepted
30 Jan 2013
First published
15 Feb 2013

Dalton Trans., 2013,42, 4357-4360

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Straightforward approach to efficient oxidative DNA cleaving agents based on Cu(II) complexes of heterosubstituted cyclens

J. Hormann, C. Perera, N. Deibel, D. Lentz, B. Sarkar and N. Kulak, Dalton Trans., 2013, 42, 4357 DOI: 10.1039/C3DT32857K

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