BODIPY–phosphane as a versatile tool for easy access to new metal-based theranostics

Semra Tasan; Olivier Zava; Benoît Bertrand; Claire Bernhard; Christine Goze; Michel Picquet; Pierre Le Gendre; Pierre Harvey; Franck Denat; Angela Casini; Ewen Bodio

doi:10.1039/C2DT32055J

BODIPY–phosphane as a versatile tool for easy access to new metal-based theranostics†

Semra Tasan,^a Olivier Zava,^b Benoît Bertrand,^a Claire Bernhard,^a Christine Goze,^a Michel Picquet,^a Pierre Le Gendre,^a Pierre Harvey,^c Franck Denat,^a Angela Casini*^d and Ewen Bodio*^a

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* Corresponding authors

^a Institut de Chimie Moléculaire de l'Université de Bourgogne, UMR 6302 CNRS, Université de Bourgogne, 9 avenue A. Savary, BP47870, 21078 Dijon, France
E-mail: ewen.bodio@u-bourgogne.fr
Fax: +33 380396117
Tel: +33 380393773

^b Institut des Sciences et Ingénierie Chimiques, École Polytechnique Fédérale de Lausanne (EPFL), CH-1015 Lausanne, Switzerland

^c Département de Chimie, Université de Sherbrooke, Sherbrooke, Québec, Canada

^d Research Institute of Pharmacy, University of Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands
E-mail: a.casini@rug.nl

Abstract

A new BODIPY–phosphane was synthesized and proved to be a versatile tool for imaging organometallic complexes. It also led to easy access to a new family of theranostics, featuring gold, ruthenium and osmium complexes. The compounds’ cytotoxicity was tested on cancer cells, and their cell uptake was followed by fluorescence microscopy in vitro.

This article is part of the themed collection: Chemistry and applications of metal complexes

Dalton Transactions

BODIPY–phosphane as a versatile tool for easy access to new metal-based theranostics†

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BODIPY–phosphane as a versatile tool for easy access to new metal-based theranostics

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