Jump to main content
Jump to site search

Issue 2, 2013
Previous Article Next Article

Self-assembled metalla-rectangles bearing azodipyridyl ligands: synthesis, characterization and antitumor activity

Author affiliations

Abstract

Sixteen arene–Ru based molecular-rectangles were self-assembled in high yields by the equimolar mixing of arene–Ru acceptors (Aa–Ad) with various azopyridyl ligands (1,2-di(pyridyl-4yl)diazene (L1), 1,2-bis(pyridin-4-ylmethylene)hydrazine (L2), 1,2-bis(1-(pyridin-4-yl)ethylidene)hydrazine (L3), 1,2-bis(pyridin-4-ylmethylene)hydrazine (L4)) in nitromethane–methanol solutions. These new molecular-rectangles were fully characterized by a host of analytical techniques including elemental analysis, 1H and 13C NMR and HR-ESI-MS. The solid-state structures of two molecular-rectangles (1b and 4d) were determined by single crystal X-ray diffraction data. UV-visible and fluorescence studies were also carried out for the entire suite of rectangles. As with recent studies of similar arene–Ru complexes, the anti-proliferative activities of these complexes were evaluated against SK-hep-1 (liver cancer) and A-549 (lung cancer) human cancer lines. Additionally, the cellular pharmacology and intracellular localizations in AGS (gastric cancer) human cancer cells were determined for selected complexes (1c, 1d and 4c) by apoptosis and fluorescence microscopy studies. These studies confirm that arene–Ru molecular-rectangles inhibit cell cycle progression to the G0 phase, in contrast to that of cisplatin which arrests cell growth in the G2 phase.

Graphical abstract: Self-assembled metalla-rectangles bearing azodipyridyl ligands: synthesis, characterization and antitumor activity

Back to tab navigation

Supplementary files

Publication details

The article was received on 09 May 2012, accepted on 11 Sep 2012 and first published on 16 Oct 2012


Article type: Paper
DOI: 10.1039/C2DT31014G
Citation: Dalton Trans., 2013,42, 466-475
  •   Request permissions

    Self-assembled metalla-rectangles bearing azodipyridyl ligands: synthesis, characterization and antitumor activity

    V. Vajpayee, S. Lee, S. Kim, S. C. Kang, T. R. Cook, H. Kim, D. W. Kim, S. Verma, M. S. Lah, I. S. Kim, M. Wang, P. J. Stang and K. Chi, Dalton Trans., 2013, 42, 466
    DOI: 10.1039/C2DT31014G

Search articles by author

Spotlight

Advertisements