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Issue 5, 2013
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Non-canonical amino acids as a useful synthetic biological tool for lipase-catalysed reactions in hostile environments

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Abstract

The incorporation of several non-canonical amino acids into the Thermoanaerobacter thermohydrosulfuricus lipase confers not only activity enhancement upon treatment with organic solvents (by up to 450%) and surfactants (resp. 1630%), but also protective effects against protein reducing (resp. 140%), alkylating (resp. 160%), and denaturing (resp.190%) agents as well as inhibitors (resp. 40%). This approach offers novel chemically diversified biocatalysts for hostile environments.

Graphical abstract: Non-canonical amino acids as a useful synthetic biological tool for lipase-catalysed reactions in hostile environments

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Publication details

The article was received on 21 Oct 2012, accepted on 13 Feb 2013 and first published on 14 Feb 2013


Article type: Communication
DOI: 10.1039/C3CY20712A
Citation: Catal. Sci. Technol., 2013,3, 1198-1201
  • Open access: Creative Commons BY-NC license
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    Non-canonical amino acids as a useful synthetic biological tool for lipase-catalysed reactions in hostile environments

    C. G. Acevedo-Rocha, M. G. Hoesl, S. Nehring, M. Royter, C. Wolschner, B. Wiltschi, G. Antranikian and N. Budisa, Catal. Sci. Technol., 2013, 3, 1198
    DOI: 10.1039/C3CY20712A

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