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Issue 13, 2013
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Electrical biosensors and the label free detection of protein disease biomarkers

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Abstract

Electrical detection methodologies are likely to underpin the progressive drive towards miniaturised, sensitive and portable biomarker detection protocols. In being easily integrated within standard electronic microfabrication formats, and developing capability in microfluidics, the facile multiplexed detection of a range of proteins in a small analytical volume becomes entirely feasible with something costing just a few thousand pounds and benchtop or handheld in scale. In this review, we focus on recent important advances in label free assays of protein using a number of electrical methods, including those based on electrochemical impedance spectroscopy (EIS), amperometry/voltammetry, potentiometry, conductometry and field-effect methods. We introduce their mechanistic features and examples of application and sensitivity. The current state of the art, real world applications and challenges are outlined.

Graphical abstract: Electrical biosensors and the label free detection of protein disease biomarkers

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Publication details

The article was received on 26 Feb 2013 and first published on 24 Apr 2013


Article type: Review Article
DOI: 10.1039/C3CS60077G
Citation: Chem. Soc. Rev., 2013,42, 5944-5962
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    Electrical biosensors and the label free detection of protein disease biomarkers

    X. Luo and J. J. Davis, Chem. Soc. Rev., 2013, 42, 5944
    DOI: 10.1039/C3CS60077G

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