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Issue 16, 2013
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Drug-loaded nanoparticles and supramolecular nanotubes formed from a volatile microemulsion with bile salt derivatives

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Abstract

The main objective of this study was to form nanoparticles of a model hydrophobic drug, celecoxib, from a volatile microemulsion stabilized by a bile salt derivative. Nanoparticles were obtained by conversion of the microemulsion nanodroplets with the dissolved drug into solid nanometric particles. The use of bile salt derivatives as the surfactants for the formation of a microemulsion enabled significantly higher loading of the drug in both the microemulsion and nanoparticles, compared with the native bile salt. In addition, superior stability of the particles was achieved with the bile salt derivatives, and drug crystallization was inhibited. Interestingly, differences in particle stability and crystallization inhibition were observed between two bile salt derivatives differing only by one hydroxyl group on the bile salt backbone, indicating the delicate balance of interactions in the system. For one of the derivatives, upon dispersion of the nanoparticles in water, they spontaneously arranged into well-defined elongated nanometric tubules as detected and attested by cryo-TEM. It was found that the drug present in nanoparticles induces formation of the nanotubes.

Graphical abstract: Drug-loaded nanoparticles and supramolecular nanotubes formed from a volatile microemulsion with bile salt derivatives

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Article information


Submitted
20 Jan 2013
Accepted
22 Feb 2013
First published
25 Feb 2013

Phys. Chem. Chem. Phys., 2013,15, 6016-6024
Article type
Paper

Drug-loaded nanoparticles and supramolecular nanotubes formed from a volatile microemulsion with bile salt derivatives

K. Margulis-Goshen, M. C. di Gregorio, N. V. Pavel, L. Abezgauz, D. Danino, J. Vázquez Tato, V. H. Soto Tellini, S. Magdassi and L. Galantini, Phys. Chem. Chem. Phys., 2013, 15, 6016
DOI: 10.1039/C3CP50258A

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