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Issue 16, 2013
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Molecular sentinel-on-chip for SERS-based biosensing

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The development of DNA detection techniques on large-area plasmonics-active platforms is critical for many medical applications such as high-throughput screening, medical diagnosis and systems biology research. Here, we report for the first time a unique “molecular sentinel-on-chip” (MSC) technology for surface-enhanced Raman scattering (SERS)-based DNA detection. This unique approach allows label-free detection of DNA molecules on chips developed on a wafer scale using large area nanofabrication methodologies. To develop plasmonics-active biosensing platforms in a repeatable and reproducible manner, we employed a combination of deep UV lithography, atomic layer deposition, and metal deposition to fabricate triangular-shaped nanowire (TSNW) arrays having controlled sub-10 nm gap nanostructures over an entire 6 inch wafer. The detection of a DNA sequence of the Ki-67 gene, a critical breast cancer biomarker, on the TSNW substrate illustrates the usefulness and potential of the MSC technology as a novel SERS-based DNA detection method.

Graphical abstract: Molecular sentinel-on-chip for SERS-based biosensing

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The article was received on 08 Jan 2013, accepted on 19 Feb 2013 and first published on 20 Feb 2013

Article type: Paper
DOI: 10.1039/C3CP00076A
Citation: Phys. Chem. Chem. Phys., 2013,15, 6008-6015
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    Molecular sentinel-on-chip for SERS-based biosensing

    H. Wang, A. Dhawan, Y. Du, D. Batchelor, D. N. Leonard, V. Misra and T. Vo-Dinh, Phys. Chem. Chem. Phys., 2013, 15, 6008
    DOI: 10.1039/C3CP00076A

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