Jump to main content
Jump to site search

Issue 23, 2013
Previous Article Next Article

Can mitochondrial dysfunction be initiated by dissociative electron attachment to xenobiotics?

Author affiliations

Abstract

Resonance attachment of low-energy electrons to xenobiotic molecules, 2,4-dichlorophenoxyacetic acid (2,4-D), dichlorodiphenyltrichloroethane (DDT) and dichlorodiphenyldichloroethylene (DDE), was investigated under gas-phase conditions by means of complementary experimental techniques. Electron transmission spectroscopy (ETS) and dissociative electron attachment spectroscopy (DEAS), in the 0–6 eV and 0–15 eV energy range, respectively, were applied with the aim of modeling the behavior of these pesticide molecules under reductive conditions in vivo. Formation of long-lived parent molecular anions and fragment negative ions was observed at incident electron energies very close to zero, in agreement with the results of density functional theory calculations. The gas-phase DEA process, analogous to dissociative electron transfer in solution, was considered as a model for the initial step which occurs in the intermembrane space of mitochondria when a xenobiotic molecule captures an electron “leaked” from the respiratory chain. A possible involvement of the fragments produced by DEA to the pesticides under investigation into cellular processes is discussed. It is concluded that the free radicals and potential DNA adducts formed by DEA are expected to be dangerous for mitochondrial functionalities, while several of the products observed could act as messenger molecules, thus interfering with the normal cellular signaling pathways.

Graphical abstract: Can mitochondrial dysfunction be initiated by dissociative electron attachment to xenobiotics?

Back to tab navigation

Supplementary files

Publication details

The article was received on 10 Feb 2013, accepted on 05 Apr 2013 and first published on 08 Apr 2013


Article type: Paper
DOI: 10.1039/C3CP50614B
Phys. Chem. Chem. Phys., 2013,15, 9125-9135

  •   Request permissions

    Can mitochondrial dysfunction be initiated by dissociative electron attachment to xenobiotics?

    S. A. Pshenichnyuk and A. Modelli, Phys. Chem. Chem. Phys., 2013, 15, 9125
    DOI: 10.1039/C3CP50614B

Search articles by author

Spotlight

Advertisements