Jump to main content
Jump to site search

Issue 39, 2013
Previous Article Next Article

Ternary and quaternary phase diagrams: key tools for chiral resolution through solution cocrystallization

Author affiliations

Abstract

The goal of this contribution is to guide the reader through the construction and the understanding of quaternary phase diagrams in the pursuit of optimal conditions for a chiral resolution through cocrystallization in solution. The overall description will be illustrated by experimental results on a system involving RS-2-(2-oxopyrrolidin-1-yl) butanamide as chiral API to be separated, and S-mandelic acid as chiral coformer.

Graphical abstract: Ternary and quaternary phase diagrams: key tools for chiral resolution through solution cocrystallization

Back to tab navigation

Supplementary files

Article information


Submitted
14 Jun 2013
Accepted
01 Aug 2013
First published
02 Aug 2013

CrystEngComm, 2013,15, 7951-7958
Article type
Paper

Ternary and quaternary phase diagrams: key tools for chiral resolution through solution cocrystallization

G. Springuel, L. Collard and T. Leyssens, CrystEngComm, 2013, 15, 7951
DOI: 10.1039/C3CE41141A

Social activity

Search articles by author

Spotlight

Advertisements