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Issue 89, 2013
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A two-directional approach to pyrrolizidines: total syntheses and biological evaluation of alkaloid cis-223B and (±)-xenovenine

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Abstract

Total syntheses of alkaloid cis-223B and xenovenine are reported in 3 and 4 steps respectively using a two-directional synthesis/triple reductive amination strategy, and their neurotoxic properties assessed.

Graphical abstract: A two-directional approach to pyrrolizidines: total syntheses and biological evaluation of alkaloid cis-223B and (±)-xenovenine

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Article information


Submitted
05 Sep 2013
Accepted
27 Sep 2013
First published
27 Sep 2013

This article is Open Access

Chem. Commun., 2013,49, 10507-10509
Article type
Communication

A two-directional approach to pyrrolizidines: total syntheses and biological evaluation of alkaloid cis-223B and (±)-xenovenine

A. Barthelme, D. Richards, I. R. Mellor and R. A. Stockman, Chem. Commun., 2013, 49, 10507
DOI: 10.1039/C3CC46800C

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