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Issue 99, 2013
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Integrating continuous microflow reactions with subsequent micropreparative separations on a single microfluidic chip

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Abstract

A current challenge in continuous flow chemistry using microfluidic devices is the combination with a micropreparative separation technique for online product clean-up and analysis. Herein we describe an approach for seamless on-chip integration of continuous flow reactors with a downstream separation functionality based on free-flow electrophoresis. A prototype device was fabricated via liquid phase lithography in a one-step procedure. This proof of concept was successfully validated by performing a model reaction of amino acids with ortho-phthaldialdehyde and continuous separation of the resulting products via micro free-flow zone electrophoresis.

Graphical abstract: Integrating continuous microflow reactions with subsequent micropreparative separations on a single microfluidic chip

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Supplementary files

Article information


Submitted
30 Aug 2013
Accepted
17 Oct 2013
First published
18 Oct 2013

Chem. Commun., 2013,49, 11644-11646
Article type
Communication

Integrating continuous microflow reactions with subsequent micropreparative separations on a single microfluidic chip

S. Jezierski, V. Tehsmer, S. Nagl and D. Belder, Chem. Commun., 2013, 49, 11644
DOI: 10.1039/C3CC46548A

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