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Issue 84, 2013
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Intramolecular arylation of amino acid enolates

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Abstract

Dianionic enolates formed from N′-aryl urea derivatives of amino acids undergo intramolecular C-arylation by attack of the enolate anion on the N′-aryl ring, leading to a hydantoin derivative of a quaternary amino acid. In situ IR studies allow identification of four intermediates on the reaction pathway.

Graphical abstract: Intramolecular arylation of amino acid enolates

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Publication details

The article was received on 13 Aug 2013, accepted on 04 Sep 2013 and first published on 05 Sep 2013


Article type: Communication
DOI: 10.1039/C3CC46193A
Citation: Chem. Commun., 2013,49, 9734-9736
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    Intramolecular arylation of amino acid enolates

    R. C. Atkinson, D. J. Leonard, J. Maury, D. Castagnolo, N. Volz and J. Clayden, Chem. Commun., 2013, 49, 9734
    DOI: 10.1039/C3CC46193A

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