Issue 88, 2013

Efficient asymmetric synthesis of lamivudine via enzymatic dynamic kinetic resolution

Abstract

The anti-HIV nucleoside lamivudine was asymmetrically synthesized in only three steps via a novel surfactant-treated subtilisin Carlsberg-catalyzed dynamic kinetic resolution protocol. The enantiomer of lamivudine could also be accessed using the same protocol catalyzed by Candida antarctica lipase B.

Graphical abstract: Efficient asymmetric synthesis of lamivudine via enzymatic dynamic kinetic resolution

Supplementary files

Article information

Article type
Communication
Submitted
22 Jul 2013
Accepted
09 Sep 2013
First published
10 Sep 2013
This article is Open Access
Creative Commons BY-NC license

Chem. Commun., 2013,49, 10376-10378

Efficient asymmetric synthesis of lamivudine via enzymatic dynamic kinetic resolution

L. Hu, F. Schaufelberger, Y. Zhang and O. Ramström, Chem. Commun., 2013, 49, 10376 DOI: 10.1039/C3CC45551C

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