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Issue 69, 2013
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Stabilization of α-helices by the self-assembly of macrocyclic peptides on the surface of gold nanoparticles for molecular recognition

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Abstract

A novel strategy to stabilize the α-helical secondary structures of peptides upon binding to gold nanoparticles is described. Using a model protein–protein interaction system, we showed that AuNPs decorated with stabilized p53 α-helix peptides can mediate specific molecular recognition with their target protein.

Graphical abstract: Stabilization of α-helices by the self-assembly of macrocyclic peptides on the surface of gold nanoparticles for molecular recognition

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Publication details

The article was received on 20 Jun 2013, accepted on 27 Jun 2013 and first published on 28 Jun 2013


Article type: Communication
DOI: 10.1039/C3CC44644A
Citation: Chem. Commun., 2013,49, 7617-7619
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    Stabilization of α-helices by the self-assembly of macrocyclic peptides on the surface of gold nanoparticles for molecular recognition

    B. Kim, S. Choi, S. Han, K. Choi and Y. Lim, Chem. Commun., 2013, 49, 7617
    DOI: 10.1039/C3CC44644A

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