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Issue 57, 2013
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Mechanical unfolding of long human telomeric RNA (TERRA)

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Abstract

We report the first single molecule investigation of TERRA molecules. By using optical-tweezers and other biophysical techniques, we have found that long RNA constructions of up to 25 GGGUUA repeats form higher order structures comprised of single parallel G-quadruplex blocks, which unfold at lower forces than their DNA counterparts.

Graphical abstract: Mechanical unfolding of long human telomeric RNA (TERRA)

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Article information


Submitted
22 Apr 2013
Accepted
28 May 2013
First published
29 May 2013

Chem. Commun., 2013,49, 6397-6399
Article type
Communication

Mechanical unfolding of long human telomeric RNA (TERRA)

M. Garavís, R. Bocanegra, E. Herrero-Galán, C. González, A. Villasante and J. R. Arias-Gonzalez, Chem. Commun., 2013, 49, 6397
DOI: 10.1039/C3CC42981D

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