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Issue 51, 2013
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Dual recognition of the human telomeric G-quadruplex by a neomycinanthraquinone conjugate

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Abstract

The authors report the recognition of a G-quadruplex formed by four repeat human telomeric DNA with aminosugar intercalator conjugates. The recognition of the G-quadruplex through dual binding mode ligands significantly increased the affinity of ligands for the G-quadruplex. One such example is a neomycinanthraquinone conjugate (2) which exhibited nanomolar affinity for the quadruplex, and the affinity of (2) is nearly 1000 fold higher for the human telomeric G-quadruplex DNA than its constituent units, neomycin and anthraquinone.

Graphical abstract: Dual recognition of the human telomeric G-quadruplex by a neomycin–anthraquinone conjugate

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Publication details

The article was received on 13 Apr 2013, accepted on 04 May 2013 and first published on 09 May 2013


Article type: Communication
DOI: 10.1039/C3CC42721H
Chem. Commun., 2013,49, 5796-5798

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    Dual recognition of the human telomeric G-quadruplex by a neomycinanthraquinone conjugate

    N. Ranjan, E. Davis, L. Xue and D. P. Arya, Chem. Commun., 2013, 49, 5796
    DOI: 10.1039/C3CC42721H

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