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Issue 43, 2013

Synthesis of a photocaged tamoxifen for light-dependent activation of Cre-ER recombinase-driven gene modification

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Abstract

We report the design of a water-soluble, quaternized tamoxifen photoprobe and demonstrate its application in light-controlled induction of green fluorescent protein expression via a Cre-ER recombinase system.

Graphical abstract: Synthesis of a photocaged tamoxifen for light-dependent activation of Cre-ER recombinase-driven gene modification

Supplementary files

Article information


Submitted
26 Mar 2013
Accepted
10 Apr 2013
First published
11 Apr 2013

Chem. Commun., 2013,49, 4971-4973
Article type
Communication

Synthesis of a photocaged tamoxifen for light-dependent activation of Cre-ER recombinase-driven gene modification

M. A. Inlay, V. Choe, S. Bharathi, N. B. Fernhoff, J. R. Baker, I. L. Weissman and S. K. Choi, Chem. Commun., 2013, 49, 4971 DOI: 10.1039/C3CC42179A

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