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Issue 67, 2013
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Influence of achiral units with gem-dimethyl substituents on the helical character of aliphatic oligourea foldamers

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Abstract

The structures of various urea oligomers incorporating one or two central achiral 1,2-diamino-1,1-dimethylethane (DADME) units have been investigated in solution and in the crystalline state. These diamine monomers are analogous to the achiral helicogenic amino acid Aib (α-aminoisobutyric acid). Oligomers were found to fold into helical conformations with DADME units inducing local deviations from the canonical helix geometry of urea foldamers.

Graphical abstract: Influence of achiral units with gem-dimethyl substituents on the helical character of aliphatic oligourea foldamers

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Publication details

The article was received on 04 Feb 2013, accepted on 21 Jun 2013 and first published on 21 Jun 2013


Article type: Communication
DOI: 10.1039/C3CC40961A
Citation: Chem. Commun., 2013,49, 7415-7417

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    Influence of achiral units with gem-dimethyl substituents on the helical character of aliphatic oligourea foldamers

    J. Fremaux, C. Dolain, B. Kauffmann, J. Clayden and G. Guichard, Chem. Commun., 2013, 49, 7415
    DOI: 10.1039/C3CC40961A

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