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Issue 27, 2013
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Endonuclease IV discriminates mismatches next to the apurinic/apyrimidinic site in DNA strands: constructing DNA sensing platforms with extremely high selectivity

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Abstract

A unique capability of Endonuclease IV in discrimination of mismatches neighboring a natural abasic site in DNA strands has been demonstrated, which enables genotyping of SNPs with high discrimination factors and differentiation of as low as 0.1–0.01% of target DNA strands from a large background of single-base different interfering strands.

Graphical abstract: Endonuclease IV discriminates mismatches next to the apurinic/apyrimidinic site in DNA strands: constructing DNA sensing platforms with extremely high selectivity

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Publication details

The article was received on 02 Feb 2013, accepted on 18 Feb 2013 and first published on 19 Feb 2013


Article type: Communication
DOI: 10.1039/C3CC40902C
Citation: Chem. Commun., 2013,49, 2819-2821

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    Endonuclease IV discriminates mismatches next to the apurinic/apyrimidinic site in DNA strands: constructing DNA sensing platforms with extremely high selectivity

    X. Xiao, Y. Liu and M. Zhao, Chem. Commun., 2013, 49, 2819
    DOI: 10.1039/C3CC40902C

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