Issue 40, 2013

Synthesis of 1,5-triazole bridged vancomycin CDE-ring bicyclic mimics using RuAAC macrocyclization

Abstract

Herein we report the Ru(II)-catalyzed double-macrocyclization of a hexapeptide to obtain a mimic of the bicyclic CDE-ring of vancomycin, followed by measurement of its binding affinity for small peptide ligands using ITC.

Graphical abstract: Synthesis of 1,5-triazole bridged vancomycin CDE-ring bicyclic mimics using RuAAC macrocyclization

Supplementary files

Article information

Article type
Communication
Submitted
24 Jan 2013
Accepted
27 Mar 2013
First published
28 Mar 2013

Chem. Commun., 2013,49, 4498-4500

Synthesis of 1,5-triazole bridged vancomycin CDE-ring bicyclic mimics using RuAAC macrocyclization

J. Zhang, J. Kemmink, D. T. S. Rijkers and R. M. J. Liskamp, Chem. Commun., 2013, 49, 4498 DOI: 10.1039/C3CC40628H

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