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Issue 20, 2013
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Drug delivery by a self-assembled DNA tetrahedron for overcoming drug resistance in breast cancer cells

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Abstract

A DNA tetrahedron is employed for efficient delivery of doxorubicin into drug-resistant breast cancer cells. The drug delivered with the DNA nanoconstruct is considerably cytotoxic, whereas free doxorubicin is virtually non-cytotoxic for the drug-resistant cells. Thus, the DNA tetrahedron, made of the inherently natural and biocompatible material, can be a good candidate for the drug carrier to overcome MDR in cancer cells.

Graphical abstract: Drug delivery by a self-assembled DNA tetrahedron for overcoming drug resistance in breast cancer cells

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Publication details

The article was received on 24 Aug 2012, accepted on 18 Jan 2013 and first published on 21 Jan 2013


Article type: Communication
DOI: 10.1039/C3CC38693G
Citation: Chem. Commun., 2013,49, 2010-2012
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    Drug delivery by a self-assembled DNA tetrahedron for overcoming drug resistance in breast cancer cells

    K. Kim, D. Kim, T. Lee, J. Y. Yhee, B. Kim, I. C. Kwon and D. Ahn, Chem. Commun., 2013, 49, 2010
    DOI: 10.1039/C3CC38693G

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