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Issue 24, 2013
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A conceptual framework for analysing and planning synthetic approaches to diverse lead-like scaffolds

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Abstract

Historically, chemists' exploration of chemical space has been exceptionally uneven and unsystematic. This feature article outlines a comprehensive conceptual framework that may be used to capture, analyse and plan synthetic approaches that may address this historically uneven exploration. Illustrative examples of synthetic approaches that target, or have potential to target, broad tracts of lead-like chemical space are presented within the context of this conceptual framework. Particular emphasis is placed on synthetic approaches that enable the combinatorial variation of molecular scaffold, particularly within the boundaries of lead-like chemical space.

Graphical abstract: A conceptual framework for analysing and planning synthetic approaches to diverse lead-like scaffolds

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Publication details

The article was received on 13 Nov 2012, accepted on 13 Dec 2012 and first published on 16 Jan 2013


Article type: Feature Article
DOI: 10.1039/C2CC38184B
Citation: Chem. Commun., 2013,49, 2383-2393

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    A conceptual framework for analysing and planning synthetic approaches to diverse lead-like scaffolds

    P. MacLellan and A. Nelson, Chem. Commun., 2013, 49, 2383
    DOI: 10.1039/C2CC38184B

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