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Issue 4, 2013
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Controlling the function of DNA nanostructures with specific trigger sequences

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Abstract

We report a hybridization-based switching mechanism with single-base specificity that can be readily integrated with functional DNA nanostructures. As an exemplar, we have developed a switchable DNAzyme (SDZ) that only becomes activated in the presence of a perfectly matched trigger sequence and operates effectively at room temperature.

Graphical abstract: Controlling the function of DNA nanostructures with specific trigger sequences

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Article information


Submitted
21 Sep 2012
Accepted
13 Nov 2012
First published
28 Nov 2012

Chem. Commun., 2013,49, 397-399
Article type
Communication

Controlling the function of DNA nanostructures with specific trigger sequences

S. Deborggraeve, J. Y. Dai, Y. Xiao and H. T. Soh, Chem. Commun., 2013, 49, 397
DOI: 10.1039/C2CC36878A

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