Issue 13, 2014
From the journal:

Chemical Communications

Complex single-chain polymer topologies locked by positionable twin disulfide cyclic bridges†

Olga Shishkan,a   Mirela Zamfir,a   Marc Andre Gauthier,b   Hans G. Börnerc  and  Jean-François Lutz*a  

* Corresponding authors

a Precision Macromolecular Chemistry Group, Institut Charles Sadron, 23 rue du Loess, BP84047, 67034 Strasbourg Cedex 2, France
E-mail: jflutz@unistra.fr
Fax: +33 3 88 41 40 99
Tel: +33 88 41 40 16

b Institut National de la Recherche Scientifique, Energie, Materiaux, Telecommunications Research Center, 1650 boul. Lionel-Boulet, Varennes (Québec) J3X 1S2, Canada

c Humboldt-Universität zu Berlin, Department of Chemistry/Laboratory for Organic Synthesis of Functional Systems, Brook-Taylor-Str. 2, 12489 Berlin, Germany

Abstract

Oligomers containing the peptide sequence cysteine–any–cysteine (CXC) were attached, at specific locations, to a linear chain of polystyrene. The polymer-bound peptide motifs were then oxidized under dilute conditions to afford a complex bio-hybrid bi-cyclic topology via intramolecular twin disulfide bridge formation.

Graphical abstract: Complex single-chain polymer topologies locked by positionable twin disulfide cyclic bridges

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Article information

DOI
https://doi.org/10.1039/C3CC47807F
Article type
Communication
Submitted
10 Oct 2013
Accepted
04 Dec 2013
First published
04 Dec 2013

Chem. Commun., 2014,50, 1570-1572

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Complex single-chain polymer topologies locked by positionable twin disulfide cyclic bridges

O. Shishkan, M. Zamfir, M. A. Gauthier, H. G. Börner and J. Lutz, Chem. Commun., 2014, 50, 1570 DOI: 10.1039/C3CC47807F

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