Issue 97, 2013
From the journal:

Chemical Communications

Structural insights into the interaction of platinum-based inhibitors with the Alzheimer's disease amyloid-β peptide†

Victor A. Streltsov,*a   V. Chandana Epa,a   Simon A. James,a   Quentin I. Churches,a   Joanne M. Caine,a   Vijaya B. Kencheb  and  Kevin J. Barnhamb  

* Corresponding authors

a CSIRO Materials Science & Engineering and Preventative-Health Flagship, Parkville, Victoria 3052, Australia
E-mail: Victor.Streltsov@csiro.au
Fax: +61 396627347
Tel: +61 396627311

b Florey Institute of Mental Health and Bio21 Molecular Science & Biotechnology Institute, University of Melbourne, Parkville, Victoria 3050, Australia

Abstract

Extended X-ray absorption fine structure spectroscopy, mass spectrometry, dynamic light scattering and density functional theory are combined to derive structural models for the interaction of neurotoxicity-ablating platinum-based compounds with the amyloid-β peptide.

Graphical abstract: Structural insights into the interaction of platinum-based inhibitors with the Alzheimer's disease amyloid-β peptide

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Article information

DOI
https://doi.org/10.1039/C3CC47326K
Article type
Communication
Submitted
25 Sep 2013
Accepted
22 Oct 2013
First published
23 Oct 2013
This article is Open Access
Creative Commons BY-NC license

Chem. Commun., 2013,49, 11364-11366

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Structural insights into the interaction of platinum-based inhibitors with the Alzheimer's disease amyloid-β peptide

V. A. Streltsov, V. Chandana Epa, S. A. James, Q. I. Churches, J. M. Caine, V. B. Kenche and K. J. Barnham, Chem. Commun., 2013, 49, 11364 DOI: 10.1039/C3CC47326K

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