Issue 3, 2014

A 1,3-amino group migration route to form acrylamidines

Abstract

A novel 1,3-amino group migration strategy for the synthesis of acrylamidines is presented. Cu(I) catalyzed reaction of N,N-disubstituted propargylamine with tosylazide generates a highly reactive ketenimine intermediate which is trapped by a tethered amino group leading to the rearrangement reaction.

Graphical abstract: A 1,3-amino group migration route to form acrylamidines

Supplementary files

Article information

Article type
Communication
Submitted
19 Sep 2013
Accepted
30 Oct 2013
First published
30 Oct 2013

Chem. Commun., 2014,50, 323-325

A 1,3-amino group migration route to form acrylamidines

D. P. Chauhan, S. J. Varma, A. Vijeta, P. Banerjee and P. Talukdar, Chem. Commun., 2014, 50, 323 DOI: 10.1039/C3CC47182A

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