Issue 86, 2013
From the journal:

Chemical Communications

The mode of action of anticancer gold-based drugs: a structural perspective†

Luigi Messori,a   Federica Scaletti,a   Lara Massai,a   Maria A. Cinellu,b   Chiara Gabbiani,c   Alessandro Vergarad  and  Antonello Merlino*d  

* Corresponding authors

a Department of Chemistry, University of Florence, Via della Lastruccia 3, 50019 Sesto Fiorentino (FI), Italy

b Department of Chemistry and Pharmacy, University of Sassari, Via Vienna 2, 07100 Sassari (SS), Italy

c Department of Chemistry and Industrial Chemistry, University of Pisa, Via Risorgimento 35, 56126 Pisa, Italy

d Department of Chemical Sciences, University of Naples Federico II, Complesso Universitario di Monte Sant'Angelo, Via cintia, Napoli, Italy
E-mail: antonello.merlino@unina.it
Fax: +39 081674090
Tel: +39 081674276

Abstract

The interactions between a few representative gold-based drugs and hen egg white lysozyme were studied by X-ray crystallography. High resolution crystal structures solved for three metallodrug–protein adducts provide valuable insight into the molecular mechanism of these promising metal compounds and the inherent protein metalation processes.

Graphical abstract: The mode of action of anticancer gold-based drugs: a structural perspective

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Article information

DOI
https://doi.org/10.1039/C3CC46400H
Article type
Communication
Submitted
21 Aug 2013
Accepted
29 Aug 2013
First published
30 Aug 2013

Chem. Commun., 2013,49, 10100-10102

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The mode of action of anticancer gold-based drugs: a structural perspective

L. Messori, F. Scaletti, L. Massai, M. A. Cinellu, C. Gabbiani, A. Vergara and A. Merlino, Chem. Commun., 2013, 49, 10100 DOI: 10.1039/C3CC46400H

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