Issue 88, 2013
From the journal:

Chemical Communications

Fluorescent and radiolabeled triphenylphosphonium probes for imaging mitochondria†

Hushan Yuan,‡a   Hoonsung Cho,‡a   Howard H. Chen,b   Marcelo Panagia,bc   David E. Sosnovikbc  and  Lee Josephson*a  

* Corresponding authors

a Center for Advanced Medical Imaging Sciences, Massachusetts General Hospital, 149 13th Street, Charlestown, MA 02129, USA
E-mail: ljosephson@mgh.harvard.edu
Tel: +1 6177266478

b Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, USA

c Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston MA, USA

Abstract

Triphenylphosphonium-fluorochromes (TPP-fluorochromes) are a new class of spectrally variable, mitochondrially targeted probes, with an [18F] labeling option which, when enabled, allows imaging of a cardiac perfusion deficit using PET/CT.

Graphical abstract: Fluorescent and radiolabeled triphenylphosphonium probes for imaging mitochondria

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Article information

DOI
https://doi.org/10.1039/C3CC45802D
Article type
Communication
Submitted
30 Jul 2013
Accepted
10 Sep 2013
First published
27 Sep 2013

Chem. Commun., 2013,49, 10361-10363

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Fluorescent and radiolabeled triphenylphosphonium probes for imaging mitochondria

H. Yuan, H. Cho, H. H. Chen, M. Panagia, D. E. Sosnovik and L. Josephson, Chem. Commun., 2013, 49, 10361 DOI: 10.1039/C3CC45802D

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