Issue 79, 2013
From the journal:

Chemical Communications

Flexible access to conformationally-locked bicyclic morpholines†

Rachael Bogacki,a   Duncan M. Gill,*b   William J. Kerr,*a   Scott Lamont,c   John A. Parkinsona  and  Laura C. Patersona  

* Corresponding authors

a Department of Pure and Applied Chemistry, WestCHEM, University of Strathclyde, 295 Cathedral Street, Glasgow, Scotland, UK
E-mail: w.kerr@strath.ac.uk
Fax: +44 (0)141 548 4822
Tel: +44 (0)141 548 2959

b Department of Chemical and Biological Sciences, University of Huddersfield, Queensgate, Huddersfield, England, UK
E-mail: d.m.gill@hud.ac.uk
Fax: +44 (0)1484 472182
Tel: +44 (0)1484 473337

c Pharmaceutical Development, AstraZeneca Alderley Park, Macclesfield, England, UK

Abstract

A preparatively accessible route to a series of conformationally-locked bicyclic morpholines has been developed. This flexible approach allows for diversification in order for a small array of lead-like scaffolds to be synthesised from readily available key building blocks.

Graphical abstract: Flexible access to conformationally-locked bicyclic morpholines

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Article information

DOI
https://doi.org/10.1039/C3CC45627G
Article type
Communication
Submitted
24 Jul 2013
Accepted
15 Aug 2013
First published
15 Aug 2013

Chem. Commun., 2013,49, 8931-8933

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Flexible access to conformationally-locked bicyclic morpholines

R. Bogacki, D. M. Gill, W. J. Kerr, S. Lamont, J. A. Parkinson and L. C. Paterson, Chem. Commun., 2013, 49, 8931 DOI: 10.1039/C3CC45627G

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