Issue 80, 2013
From the journal:

Chemical Communications

A rapid screen for molecules that form duplex to duplex crosslinks in DNA†

María J. Marín,‡a   Benjamin D. Rackham,‡b   Andrew N. Round,b   Lesley A. Howell,b   David A. Russell*a  and  Mark Searcey*b  

* Corresponding authors

a School of Chemistry, University of East Anglia, Norwich Research Park, Norwich NR4 7TJ, UK
E-mail: d.russell@uea.ac.uk

b School of Pharmacy, University of East Anglia, Norwich Research Park, Norwich NR4 7TJ, UK
E-mail: m.searcey@uea.ac.uk
Fax: +44 (0)1603 592009
Tel: +44 (0)1603 592026

Abstract

We describe a gold nanoparticle based assay that can rapidly determine the crosslinking of DNA duplexes by ligands. Such compounds have potential in targeting highly compacted DNA such as that found in the nucleosome.

Graphical abstract: A rapid screen for molecules that form duplex to duplex crosslinks in DNA

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Article information

DOI
https://doi.org/10.1039/C3CC45600E
Article type
Communication
Submitted
23 Jul 2013
Accepted
22 Aug 2013
First published
22 Aug 2013
This article is Open Access
Creative Commons BY license

Chem. Commun., 2013,49, 9113-9115

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A rapid screen for molecules that form duplex to duplex crosslinks in DNA

M. J. Marín, B. D. Rackham, A. N. Round, L. A. Howell, D. A. Russell and M. Searcey, Chem. Commun., 2013, 49, 9113 DOI: 10.1039/C3CC45600E

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