The anti-HIV nucleoside lamivudine was asymmetrically synthesized in only three steps via a novel surfactant-treated subtilisin Carlsberg-catalyzed dynamic kinetic resolution protocol. The enantiomer of lamivudine could also be accessed using the same protocol catalyzed by Candida antarctica lipase B.
L. Hu, F. Schaufelberger, Y. Zhang and O. Ramström, Chem. Commun., 2013, 49, 10376 DOI: 10.1039/C3CC45551C
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