On the basis of a dual-amplification strategy, microRNA (miRNA) hybridization amplification by a duplex-specific nuclease (DSN) and signal amplification by a DNAzyme, a highly sensitive and selective homogeneous miRNA assay is developed. By leveraging on the cumulative and selective nature of the DSN amplification process, excellent sensitivity and selectivity are accomplished.
H. Deng, Y. Ren, W. Shen and Z. Gao, Chem. Commun., 2013, 49, 9401 DOI: 10.1039/C3CC44824J
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