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Issue 83, 2013
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A chemical genomics approach to identification of interactions between bioactive molecules and alternative reading frame proteins

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Abstract

Magic TagĀ® immobilisation of bioactive molecules coupled with bacteriophage display, followed by an ELISA assay, provides a protocol that can probe interactions of drugs with putative products of alternative initiation of translation as exemplified by the binding of immobilised flecainide to protein products of genes linked to sudden cardiac death.

Graphical abstract: A chemical genomics approach to identification of interactions between bioactive molecules and alternative reading frame proteins

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Publication details

The article was received on 20 Jun 2013, accepted on 30 Aug 2013 and first published on 02 Sep 2013


Article type: Communication
DOI: 10.1039/C3CC44647F
Citation: Chem. Commun., 2013,49, 9588-9590
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    A chemical genomics approach to identification of interactions between bioactive molecules and alternative reading frame proteins

    P. C. Taylor, A. J. Clark, A. Marsh, D. R. J. Singer and S. J. Dilly, Chem. Commun., 2013, 49, 9588
    DOI: 10.1039/C3CC44647F

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