Pd-catalyzed addition of boronic acids to ynolethers: a highly regio- and stereoselective synthesis of trisubstituted vinyl ethers

Abstract

A Pd-catalyzed addition of boronic acids to ynol ethers has been realized, delivering trisubstituted vinyl ethers in good yields with perfect control of the regio- and stereoselectivity. The reaction proceeds under mild conditions and exhibits excellent functional group compatibility. Moreover, the resultant products can be converted into pentasubstituted benzenes via the tandem Diels–Alder/aromatization reaction.