Issue 65, 2013

Organocatalytic asymmetric multicomponent cascade reaction via 1,3-proton shift and [3+2] cycloaddition: an efficient strategy for the synthesis of oxindole derivatives

Abstract

An efficient and powerful organocatalytic cascade reaction was achieved for the synthesis of biologically important chiral spiro[pyrrolidin-3,2′-oxindoles] using very simple and readily available starting materials. Three C–C bonds and four contiguous stereogenic centers including one quaternary stereocenter were established in a single operation with reasonable yields and good stereoselectivity.

Graphical abstract: Organocatalytic asymmetric multicomponent cascade reaction via 1,3-proton shift and [3+2] cycloaddition: an efficient strategy for the synthesis of oxindole derivatives

Supplementary files

Article information

Article type
Communication
Submitted
18 May 2013
Accepted
18 Jun 2013
First published
18 Jun 2013

Chem. Commun., 2013,49, 7213-7215

Organocatalytic asymmetric multicomponent cascade reaction via 1,3-proton shift and [3+2] cycloaddition: an efficient strategy for the synthesis of oxindole derivatives

L. Tian, X. Hu, Y. Li and P. Xu, Chem. Commun., 2013, 49, 7213 DOI: 10.1039/C3CC43755H

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