Synthesis of (spiro)cyclopentapyridinones via Csp3–H functionalization: a post-Ugi gold-catalyzed regioselective tandem cyclization

Dipak D. Vachhani; Marzia Galli; Jeroen Jacobs; Luc Van Meervelt; Erik V. Van der Eycken

doi:10.1039/C3CC43418D

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Synthesis of (spiro)cyclopentapyridinones via C_sp³–H functionalization: a post-Ugi gold-catalyzed regioselective tandem cyclization†

Dipak D. Vachhani,^a Marzia Galli,^a Jeroen Jacobs,^b Luc Van Meervelt^b and Erik V. Van der Eycken*^a

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* Corresponding authors

^a Laboratory for Organic & Microwave-Assisted Chemistry (LOMAC), Department of Chemistry, University of Leuven (KU Leuven), Celestijnenlaan 200F, B-3001, Leuven, Belgium
E-mail: erik.vandereycken@chem.kuleuven.be

^b Biomolecular Architecture, Department of Chemistry, University of Leuven (KU Leuven), Celestijnenlaan 200F, B-3001, Leuven, Belgium

Abstract

A gold-catalyzed regioselective tandem cyclization of N-propynylbutynamide via C_sp³–H functionalization has been described, providing a distinctive methodology for the architecture of cyclopentapyridinones as well as spirocyclopentapyridinones.

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Article information

DOI: https://doi.org/10.1039/C3CC43418D
Article type: Communication
Submitted: 08 May 2013
Accepted: 29 May 2013
First published: 30 May 2013

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Chem. Commun., 2013,49, 7171-7173

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Synthesis of (spiro)cyclopentapyridinones via C_sp³–H functionalization: a post-Ugi gold-catalyzed regioselective tandem cyclization

D. D. Vachhani, M. Galli, J. Jacobs, L. Van Meervelt and E. V. Van der Eycken, Chem. Commun., 2013, 49, 7171 DOI: 10.1039/C3CC43418D

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