Room temperature and solvent-free iridium-catalyzed selective alkylation of anilines with alcohols

Abstract

A bidentate iridium NHC–phosphine complex has been developed and applied to the N-monoalkylation of aromatic amines with a wide range of primary alcohols and to the N-heterocyclization of amino alcohols. This reaction resulted in high isolated product yields, even at room temperature and under solvent-free conditions.