Issue 54, 2013
From the journal:

Chemical Communications

Copper/TEMPO catalysed synthesis of nitriles from aldehydes or alcohols using aqueous ammonia and with air as the oxidant†‡

Laura M. Dornan,a   Qun Cao,a   James C. A. Flanagan,§a   James J. Crawford,b   Matthew J. Cook*a  and  Mark J. Muldoon*a  

* Corresponding authors

a School of Chemistry and Chemical Engineering, Queen's University Belfast, David Keir Building, Stranmillis Road, Belfast, UK
E-mail: m.j.muldoon@qub.ac.uk, m.cook@qub.ac.uk

b Department of Medicinal Chemistry, AstraZeneca R & D, Charnwood, Bakewell Rd, Loughborough, UK

Abstract

Copper/TEMPO catalysts can be used to prepare nitriles from aldehydes or alcohols using aqueous ammonia. Readily accessible methods were developed that enable standard glassware to be used with air as the source of O2. It was further shown that, at higher temperatures in a pressurised reactor under limiting oxygen conditions (8% O2), catalyst loadings of 1 mol% could be employed.

Graphical abstract: Copper/TEMPO catalysed synthesis of nitriles from aldehydes or alcohols using aqueous ammonia and with air as the oxidant

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Article information

DOI
https://doi.org/10.1039/C3CC42231C
Article type
Communication
Submitted
27 Mar 2013
Accepted
22 May 2013
First published
23 May 2013
This article is Open Access
Creative Commons BY license

Chem. Commun., 2013,49, 6030-6032

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Copper/TEMPO catalysed synthesis of nitriles from aldehydes or alcohols using aqueous ammonia and with air as the oxidant

L. M. Dornan, Q. Cao, J. C. A. Flanagan, J. J. Crawford, M. J. Cook and M. J. Muldoon, Chem. Commun., 2013, 49, 6030 DOI: 10.1039/C3CC42231C

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