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Issue 45, 2013
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Reversible chemoselective tagging and functionalization of methionine containing peptides

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Abstract

Reagents were developed to allow chemoselective tagging of methionine residues in peptides and polypeptides, subsequent bioorthogonal functionalization of the tags, and cleavage of the tags when desired. This methodology can be used for triggered release of therapeutic peptides, or release of tagged protein digests from affinity columns.

Graphical abstract: Reversible chemoselective tagging and functionalization of methionine containing peptides

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Publication details

The article was received on 26 Mar 2013, accepted on 19 Apr 2013 and first published on 23 Apr 2013


Article type: Communication
DOI: 10.1039/C3CC42214C
Citation: Chem. Commun., 2013,49, 5144-5146

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    Reversible chemoselective tagging and functionalization of methionine containing peptides

    J. R. Kramer and T. J. Deming, Chem. Commun., 2013, 49, 5144
    DOI: 10.1039/C3CC42214C

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