Issue 43, 2013
From the journal:

Chemical Communications

Synthesis of a photocaged tamoxifen for light-dependent activation of Cre-ER recombinase-driven gene modification†

Matthew A. Inlay,*a   Veronica Choe,b   Sophia Bharathi,bc   Nathaniel B. Fernhoff,a   James R. Baker, Jr.,bc   Irving L. Weissmana  and  Seok Ki Choi*bc  

* Corresponding authors

a Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
E-mail: minlay@stanford.edu
Fax: +1 650 498-6255
Tel: +1 650 725-5808

b Michigan Nanotechnology Institute for Medicine and Biological Sciences, University of Michigan, Ann Arbor, MI 48109, USA

c Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA
E-mail: skchoi@umich.edu
Fax: +1 734 615-0621
Tel: +1 734 615-0618

Abstract

We report the design of a water-soluble, quaternized tamoxifen photoprobe and demonstrate its application in light-controlled induction of green fluorescent protein expression via a Cre-ER recombinase system.

Graphical abstract: Synthesis of a photocaged tamoxifen for light-dependent activation of Cre-ER recombinase-driven gene modification

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C3CC42179A
Article type
Communication
Submitted
26 Mar 2013
Accepted
10 Apr 2013
First published
11 Apr 2013

Chem. Commun., 2013,49, 4971-4973

Permissions

Request permissions

Synthesis of a photocaged tamoxifen for light-dependent activation of Cre-ER recombinase-driven gene modification

M. A. Inlay, V. Choe, S. Bharathi, N. B. Fernhoff, J. R. Baker, I. L. Weissman and S. K. Choi, Chem. Commun., 2013, 49, 4971 DOI: 10.1039/C3CC42179A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements