Issue 35, 2013

A regioselective synthesis of 1-haloisoquinolines via ruthenium-catalyzed cyclization of O-methylbenzohydroximoyl halides with alkynes

Abstract

A ruthenium-catalyzed highly regioselective cyclization of substituted N-methoxy benzimidoyl halides with alkynes in the presence of CsOAc (25 mol%) to give substituted 1-halo and 1-alkoxy substituted isoquinolines in good to excellent yields is described.

Graphical abstract: A regioselective synthesis of 1-haloisoquinolines via ruthenium-catalyzed cyclization of O-methylbenzohydroximoyl halides with alkynes

Supplementary files

Article information

Article type
Communication
Submitted
18 Feb 2013
Accepted
13 Mar 2013
First published
14 Mar 2013

Chem. Commun., 2013,49, 3703-3705

A regioselective synthesis of 1-haloisoquinolines via ruthenium-catalyzed cyclization of O-methylbenzohydroximoyl halides with alkynes

R. K. Chinnagolla, S. Pimparkar and M. Jeganmohan, Chem. Commun., 2013, 49, 3703 DOI: 10.1039/C3CC41269E

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